Selank
A synthetic heptapeptide analogue of the immunoregulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro tail.
- Purity
- 99.2%
- Lot
- PU-7694
- CAS
- 129954-34-3
- MW
- 751.90 g/mol
- Format
- Lyophilized powder
- Third-party tested
- Discreet packaging
- Same-day shipping
- Encrypted checkout
For research use only. Not for human consumption.
Mechanism of Action
Selank is an analogue of tuftsin - the immunoregulatory tetrapeptide Thr-Lys-Pro-Arg - extended with proline-glycine-proline for stability. The tuftsin literature, reviewed in Current Medicinal Chemistry in 2017, establishes the parent peptide as an immune-modulating fragment of immunoglobulin G.
Published mechanistic work has examined expression of inflammation-related genes in spleen, hippocampal transcriptome changes, effects on GABAergic neurotransmission gene expression, and interaction with brain serotonin metabolism in rodents.
Research Findings
Rodent studies have examined anxiety paradigms under unpredictable chronic mild stress, ethanol-induced memory impairment, and aversive signs of morphine withdrawal. Endpoints were behavioural and transcriptional.
A small Russian-language clinical literature compared the peptide with phenazepam in anxiety disorders. As with Semax, the primary record is concentrated in a limited set of laboratories and languages.
Storage & Reconstitution
Sealed lyophilized vials are stored in the dark. The peptide-formulation literature regards the dry solid as the stable state and the solution as the fragile one: refrigeration at 2-8 degrees C is standard for short holding periods, and minus 20 degrees C or colder for long-term storage. Vials are brought to room temperature before opening so that atmospheric moisture does not condense onto the cold solid.
For reconstitution, the diluent is added slowly down the inner wall of the vial rather than directly onto the cake, and the vial is swirled rather than shaken - agitation at an air-liquid interface is a well-documented driver of peptide aggregation. The solid should dissolve to a clear, particle-free solution; persistent cloudiness or visible particulate indicates the material should not be used.
Reconstituted solution is held at 2-8 degrees C and protected from light. Freeze-thaw cycling is the single most avoidable cause of loss, so where a solution must be frozen it is aliquoted first into single-use volumes. Working aliquots are labelled with the lot number so that any result can be traced back to the certificate of analysis for that lot.
- Physical form
- Lyophilized powder, sealed vial
- Sealed storage
- 2-8 C short term / -20 C long term
- Reconstituted
- 2-8 C, protected from light
- Diluent
- Bacteriostatic water, added down the vial wall
- Avoid
- Shaking, freeze-thaw cycling, direct light
Handling summary
References
Every entry below links to its PubMed record. Publication is not endorsement: several of these papers report limitations, negative findings or adverse events, and they are listed for that reason.
- [1]Functional Connectomic Approach to Studying Selank and Semax Effects(opens PubMed in a new tab)
Dokl Biol Sci · 2020 · PMID 32342318
- [2]Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats(opens PubMed in a new tab)
Bull Exp Biol Med · 2022 · PMID 36322304
- [3]Tuftsin - Properties and Analogs(opens PubMed in a new tab)
Curr Med Chem · 2017 · PMID 28745220
- [4]The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action(opens PubMed in a new tab)
Mol Immunol · 2014 · PMID 24291245
- [5]Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank(opens PubMed in a new tab)
Regul Pept · 2011 · PMID 21609736
- [6]